Pesticide misuse in Kano State poses a threat to both human health and agricultural trade. This is partly because grain handlers often lack training and overlook safer integrated pest management (IPM) practices. A purposive multi stage sampling technique was employed to select 120 pesticide handlers across 12 market commodity lines, and the collected data were analysed using SPSS and Microsoft Excel. Findings reveal critical gaps in pesticide handling at Dawanau Market, Kano. Although 64.2% use protective gear and 61.7% follow dosage instructions, 57.5% rarely use manuals, and 51.7% mix solutions incorrectly. Limited access to personal protective equipment, illiteracy, and poor exposure response highlighted the need for improved training and stricter regulation. Despite this, nearly half lacked formal training in pesticide use, pointing to a significant training gap. Approximately 81.7% of pesticides used were purchased from licensed vendors and stored properly; however, some handlers still stored them within living spaces, posing health risks. Preliminary awareness of first-aid procedures was evident, whereas understanding of safety label signals demonstrated variability. To address these, tailored training programs, supportive policy measures, and greater engagement in professional organisations are essential. Implementing these measures will help protect the health of handlers and the environment, while also boosting the quality and marketability of agricultural produce from Dawanau Market, Kano State.